He is a two-time world heavy weight champion, having held the WBC and The Ring magazine titles since defeating Deontay Wilder in 2020; previously he held the unified WBA (Super), IBF, WBO, IBO and The Ring titles after defeating Wladimir Klitschko in 2015. With his defeat of Wilder, Fury became the third heavyweight, after Floyd Patterson and Muhammad Ali, to hold The Ring magazine title twice, and is widely considered by media outlets to be the lineal heavyweight champion. As of November 2021, Fury is ranked as the world's best active heavyweight by ESPN, the Transnational Boxing Rankings Board (TBRB) and BoxRec. He is ranked as the third-best active boxer, pound for pound, by BoxRec.

In 2016, he vacated the WBA, WBO and IBO titles; The Ring stripped him of his last remaining title in early 2018. Later that year, after more than two years of inactivity, Fury challenged for the WBC heavyweight title against Wilder. The fight was controversially scored as a draw. Fury's strong performance against Wilder (including recovering from a heavy knockdown in the final round) earned him Comeback of the Year from The Ring and numerous other awards. In the rematch in February 2020, Fury defeated Wilder by a technical knockout in the seventh round after a dominant performance. He knocked out Wilder again in the trilogy fight in October 2021, this time in the 11th round.

On April 23rd 2022, Fury landed a left jab, followed by a right uppercut which sent Whyte sprawling to the canvas. Although Whyte was able to beat the count and rise to his feet, the referee deemed it unsafe for him to continue, halting the fight after two minutes and fifty-nine seconds of the sixth round, declaring Fury the winner by sixth-round technical knockout, remaining undefeated.